2026
Tuning tRNA synthetase inhibition reveals parabolic induction of stress granules limited in size and RNA content
Max Baymiller, Noah S. Helton, Benjamin Dodd, and Stephanie L Moon†
RNA
Available online ahead of print here
tRNA synthetase activity is required for stress granule and P-body assembly
Max Baymiller, Noah S. Helton, Benjamin Dodd, and Stephanie L Moon†
Genes & Development
2025
Ribosome association inhibits stress-induced gene mRNA localization to stress granules
Noah S. Helton, Benjamin Dodd, and Stephanie L Moon†
Genes & Development
-Highlighted in the University of Michigan “RNA Transcript”
-Highlighted in the University of Michigan Medicine “Health Lab”
tRNA synthetase activity is required for stress granule and P-body assembly
Max Baymiller, Noah S. Helton, Benjamin Dodd, and Stephanie L Moon†
Preprint on bioRxiv
-Highlighted as a Life Science Editors Foundation ‘prepraise’ article
-Highlighted as a Prelight by The Company of Biologists
2024
Stress-Induced Gene mRNA Condensation and Expression are Governed by Ribosome Association and the Stress Granule Proteins G3BP1/2
Noah S. Helton, Benjamin Dodd, and Stephanie L Moon†
Preprint on Cell Press Sneak Peak
Stress granules as causes and consequences of translation suppression
Max Baymiller and Stephanie L Moon†
Antioxidants & Redox Signaling
2022
Is bRaQCing bad? New roles for ribosome associated quality control factors in stress granule regulation
Noah S Helton and Stephanie L Moon†
Biochemical Society Transactions, BST20220549
The final version of record is available here.
Measuring Bulk Translation Activity in Single Mammalian Cells During the Integrated Stress Response
Alyssa M English and Stephanie L Moon†
The Integrated Stress Response: Methods and Protocols
Methods in Molecular Biology, vol. 2428
2021
A (dis)integrated stress response: Genetic diseases of eIF2α regulators
Alyssa M English, Katelyn M Green, Stephanie L Moon†
Wiley Interdisciplinary Reviews: RNA e1689.
2020
Coupling of translation quality control and mRNA targeting to stress granules
Stephanie L Moon†, Tatsuya Morisaki, Timothy J Stasevich, Roy Parker†
Journal of Cell Biology 218 (8)
2019
RNase L reprograms translation by widespread mRNA turnover escaped by antiviral mRNAs
James M Burke, Stephanie L Moon, Tyler Matheny, Roy Parker†
Molecular Cell 75 (6), 1203-1217. e5
Multicolour single-molecule tracking of mRNA interactions with RNP granules
Stephanie L Moon*, Tatsuya Morisaki*, Anthony Khong, Kenneth Lyon, Roy Parker†, Timothy J Stasevich†
Nature Cell Biology 21 (2), 162-168
See the News & Views article, “Dynamics of mRNA entry into stress granules” by Chih-Yung Lee and Geraldine Seydoux in Nature Cell Biology.
2018
Analysis of eIF2B bodies and their relationships with stress granules and P-bodies
Stephanie L Moon†, Roy Parker
Scientific Reports 8 (1), 1-14
EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response
Stephanie L Moon, Roy Parker†
RNA 24 (6), 841-852
Neuronal regulation of eIF2α function in health and neurological disorders
Stephanie L Moon, Nahum Sonenberg, Roy Parker†
Trends in Molecular Medicine 24 (6), 575-589
2015
Flavivirus sfRNA suppresses antiviral RNA interference in cultured cells and mosquitoes and directly interacts with the RNAi machinery
Stephanie L Moon, Benjamin JT Dodd, Doug E Brackney, Carol J Wilusz, Gregory D Ebel, Jeffrey Wilusz†
Virology 485, 322-329
XRN1 stalling in the 5’UTR of Hepatitis C virus and Bovine Viral Diarrhea virus is associated with dysregulated host mRNA stability
Stephanie L Moon, Jeffrey G Blackinton, John R Anderson, Mary K Dozier, Benjamin JT Dodd, Jack D Keene, Carol J Wilusz, Shelton S Bradrick, Jeffrey Wilusz†
PLoS Pathogens 11 (3), e1004708
Oxidative stress influences positive strand RNA virus genome synthesis and capping
Rebekah C Gullberg*, J Jordan Steel* Stephanie L Moon, Elnaz Soltani, Brian J Geiss†
Virology 475, 219-229
2014
The structural basis of pathogenic subgenomic flavivirus RNA (sfRNA) production
Erich G Chapman, David A Costantino, Jennifer L Rabe, Stephanie L Moon, Jeffrey Wilusz, Jay C Nix, Jeffrey S Kieft†
Science 344 (6181), 307-310
RNA structures that resist degradation by Xrn1 produce a pathogenic Dengue virus RNA
Erich G Chapman, Stephanie L Moon, Jeffrey Wilusz, Jeffrey S Kieft†
eLife 3, e01892
2013
Cytoplasmic viruses: rage against the (cellular RNA decay) machine
Stephanie L Moon, Jeffrey Wilusz†
PLoS Pathogens 9 (12), e1003762
Changes in cellular mRNA stability, splicing, and polyadenylation through HuR protein sequestration by a cytoplasmic RNA virus
Michael D Barnhart*, Stephanie L Moon*, Alexander W Emch, Carol J Wilusz, Jeffrey Wilusz†
Cell Reports 5 (4), 909-917
In vitro transcription of modified RNAs
Stephanie L Moon, Jeffrey Wilusz†
In Vitro Transcription of Modified RNAs. In: Conn G. (eds) Recombinant and In Vitro RNA Synthesis. Methods in Molecular Biology (Methods and Protocols), vol 941.
2012
A noncoding RNA produced by arthropod-borne flaviviruses inhibits the cellular exoribonuclease XRN1 and alters host mRNA stability
Stephanie L Moon, John R Anderson, Yutaro Kumagai, Carol J Wilusz, Shizuo Akira, Alexander A Khromykh, Jeffrey Wilusz†
RNA 18 (11), 2029-2040
Inhibition and avoidance of mRNA degradation by RNA viruses
Stephanie L Moon, Michael D Barnhart, Jeffrey Wilusz†
Current Opinion in Microbiology 15 (4), 500-505
bold indicates Moon lab member; * indicates equal authorship; † indicates corresponding author